Conceptual diagram of the PESI ion source |
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| Acronym | PESI |
|---|---|
| Classification | Mass spectrometry |
| Analytes | Organic molecules Biomolecules |
| Other techniques | |
| Related | Electrospray ionization |
Probe electrospray ionization (PESI) is a modified version of conventional electrospray ionization (ESI), where the capillary for sample solution transferring is replaced by a solid needle with a sharp tip. PESI was first introduced by Kenzo Hiraoka et al. in 2007[1]. Compared with conventional electrospray ionization, high salt tolerance and direct sampling and low sample consumption can be found with PESI. Of course, PESI is not a continuous process at all. Normally, the needle for sampling and spraying can be driven up and down under a frequency of 3-5 Hz.
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